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KMID : 0360220070480050630
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Journal of the Korean Ophthalmological Society
2007 Volume.48 No. 5 p.630 ~ p.636
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Changes of Tear Parameters after Using Cyclosporine A in Dry Eye with Thyroid Ophthalmopahty
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Oh Han-Jin
You In-Cheon
Yoon Kyung-Chul
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Abstract
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Purpose: This study was performed to evaluate the changes of tear film and ocular surface after using cyclosporine A in patients with thyroid-associated ophthalmopathy accompanied by dry eye.
Methods: Corneal sensitivity test (CST), tear break-up time (BUT), basal tear secretion test (BST), fluorescein staining (FS), tear clearance rate (TCR), and conjunctival impression cytology were evaluated in 28eyes of 28 patients with thyroid-associated ophthalmopathy accompanied by dry eye before and after using 0.1 cyclosporine A.
Results: CST (P=0.03), BUT (P<0.01), and BST (P=0.01) were shown significant improvements after 3 month treatment with topical 0.1% cyclosporine A. There are also shown improvments of impression cytologic findings, reduction of the degree of conjunctival squamous cell metaplasia (P=0.02) and increment of the density of goblet cell (P=0.04) after 3 month treatment. But TCR and FS were shown no significant changes after treatment.
Conclusion: The improvement of parameters of tear films and ocular surface suggest the treatment with 0.1% cyclosporine A for dry eye in thyroid ophthalmopathy was effective. J Korean Ophthalmol Soc 48(5):630-636, 2007
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KEYWORD
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Cyclosporine A, Ocular surface, Tear film, Thyroid-associated ophthalmopathy
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